Millions of individuals are affected by insomnia around the globe. And there are too many reasons for this disorder. Despite the causes, it mainly impacts psychological performance, emotional stability, and a person’s physical health. When non-medical therapy fails, sleeping drugs such as Trazodone and Ambien are prescribed.

Both drugs serve the same purpose of treating sleeping problems. But they are distinct regarding their mechanisms, side effects, levels, safety, and long-term effects. 

This blog post presents a detailed comparison between these two drugs. It will help you gain knowledge that will allow you to make the most appropriate decision regarding the treatment option for you and your loved ones.

Ambien: A Go-To Prescription for Insomnia

Ambien is a sedative-hypnotic drug used to treat occasional insomnia. Its generic name is zolpidem. This medicine works by binding to GABA  (gamma-aminobutyric acid) receptors in the brain. This makes the brain slower, which causes a calming and sleeping effect.

Classification	Non-benzodiazepine sedative-hypnotic
FDA Approval	Approved in 1922 for the treatment of insomnia
Onset	Results in 15–30 minutes
Duration	Typically, lasts 6–8 hours

People who cannot fall asleep are usually recommended to use Ambien to treat their condition of insomnia. Although this drug is effective, it should be used in the short term. This precaution is because of its potential to form a habit. It also leads to extreme side effects like sleepwalking, constant daytime drowsiness, and mental impairments.

Which One Is More Effective?

Before we start the comparison, it is important to understand that they are prescribed under different circumstances. Therefore, the results will be highly based on usage. Also, the recommended drug might depend on the type of insomnia the person is facing.

The differentiation between these two important and most recommended drugs for better sleep is here.

Trazodone for Sleep

Trazodone is a sedative medication primarily used in off-label prescriptions as a sleeping tablet. It was initially produced as an antidepressant. Unlike Ambien, this drug cannot induce a rapid calming sense, but it helps develop deep and lasting sleep during the night.

• Mechanism of Action. Usually inhibits serotonin reuptake and blocks histamine & alpha-1 adrenergic receptors.
• Common Use. Often prescribed for patients with comorbid depression and insomnia.

Ambien for Insomnia

Ambien is widely applicable to users who have no underlying mood disorders. It encourages fast sleep, but might not be helpful to those who tend to wake up in the middle of the night.

• Mechanism of Action. It also works by inhibiting serotonin reuptake and antagonizing serotonin 5-HT2A receptors. These parts are responsible for improving serotonergic functioning in the brain.
• Common Use. It is mainly used to treat mental health conditions, but is also prescribed off-label for insomnia.

Comparing Side Effects: Trazodone Side Effects vs Ambien Side Effects

Here is a comprehensive comparison between the trazodone side effects and Ambien side effects, in the table below:

Trazodone Side Effects	Ambien Side Effects
Daytime drowsiness	Headaches
Low blood pressure	Gastrointestinal discomfort
Dry mouth	Memory impairment
Blurred vision	Risk of dependence
Priapism	Risk of withdrawal

Is Trazodone Safer Than Ambien? Safety Considerations to Know

When selecting a sleeping prescription, it is important to know the safer options. Trazodone is also widely preferred by many clinicians in cases of patients with prior problems of addiction or mental illnesses. Still, on the other hand, the danger of abuse can limit Ambien.

Safety Profile of Trazodone

• Very low risk of addiction.
• It can be helpful in the long run for sleep management.
• Better for individuals with underlying mood disorders.

Safety Profile of Ambien

• It should be used for the short term.
• Risk of tolerance, withdrawal symptoms, and accidental injury.
• It can cause sleep behaviors that pose a danger to oneself or others.

Dosage Guidelines: Trazodone Vs Ambien Dosage for Insomnia

Dosage is the key to any sleeping pill’s safe and effective performance. In the case of Trazodone, the recommended initial dose for sleep trouble is 25 to 50 mg at bedtime. 

The dose can be increased, depending on the reaction of the patient, and can reach up to 150 mg in case of insomnia. It should be mentioned that the doses used in the case of depression are of a higher potency, and the mentioned potency is not needed in the context of sleep-related issues. 

The dosage for Ambient tends to be smaller with females, beginning at 5 mg. However,  a higher dose between 5 and 10 mg is recommended for men. The extended-release version, known as the Ambien CR, comes in 6.25 to 12.5 mg. 

The medication for treating insomnia is supposed to be taken just before the sleeper goes to bed and only when they have at least 7 or 8 restful hours of sleep. When Ambien is used without a substantial time, it can induce sleep in the morning hours. 

This situation may cause an inability to remain alert the next day. Now, this scenario apparently seems fine. But it may be harmful in certain cases, like driving trucks or operating heavy machinery. To get an overview of the correct dosage, you can refer to Medline. They have also shared precautions and side effects for the Trazodone drug.

How Long Do the Effects Last?

The main difference between Ambien and Trazodone is their duration of effectiveness. Ambien’s duration of action is relatively short, usually lasting six to eight hours. This is why it is beneficial for falling asleep. However, it does not necessarily suit individuals with intense sleeping problems.

Trazodone’s effects are slow but last longer during the night. Its lasting effects make it a preferable treatment option among people who wake up frequently or have trouble sleeping. This is why doctors tend to rely on Trazodone more than on Ambien when the person is primarily concerned with maintaining sleep.

Factors to Consider While Choosing Trazodone or Ambien

The selection of appropriate drugs depends heavily on several personal and medical factors. If the primary issue is the inability to fall asleep within a short period and the issue is not persistent, Ambien can likely help with a rapid solution. However, its increased dependency and severe side effects should be considered. In simple words, it should be consumed cautiously and just for a short period of time.

In comparison, Trazodone is more suitable for long-term treatment. It is especially helpful when a patient has both sleep problems and depression. It has fewer risks of addiction, which is why it is considered a safer option. Because of all these positives, physicians also use it on individuals who have a history of mental illnesses or certain disorders.

However, a thorough medical assessment is necessary before using any of these medications. And, it should be done by a healthcare expert. The professional will examine based on the person’s specific sleep pattern, lifestyle, and general health. For reference, you can check the NLM, which states the use of Trazodone and Zolpidem for Insomnia.

Contact Touch Stone Recovery for Sleep Aid Support

Are you or your loved one having trouble sleeping? You are not the first, as many people go through the same situation. The main point is that you need not fight it alone, but now you are not alone.

At Touch Stone Recovery, we know how a lack of sleep may adversely impact all aspects of life, particularly when associated with anxiety, depression, or drug abuse. A safe and comfortable environment, our holistic and personalized treatment programs are developed to navigate the root causes of your sleeping issues and guide you through the journey.

If you are looking for a potential treatment that can help you out, we are here to assist you at every stage. Our team will guide you through evidence-based care that fits your needs. So, connect with us and begin your journey to a better and healthier lifestyle. 

FAQs

What are the common side effects of Trazodone when used for sleep?

The common side effects of Trazodone include dizziness, low blood pressure, dry mouth, and more. Most users tolerate the medication with mild to moderate side effects.

How do the side effects of Ambien compare to those of Trazodone for insomnia treatment?

Ambien’s side effects are always more extreme, including memory loss, sleepwalking, and late-day sleepiness. At the same time, Trazodone will most likely trigger more superficial effects, such as grogginess or dizziness.

Which medication, Trazodone or Ambien, is more effective for treating sleep disorders?

The results of every medication or drug vary from person to person. Ambien can treat short-term sleeping problems, and Trazodone can treat long-term issues. Both show positive results when given in the right dosage and case.

How do the safety profiles of Trazodone and Ambien differ when used for insomnia?

Trazodone is safer in the long term as individuals are less prone to dependence. On the other hand, Ambien possesses a greater liability for tolerance and abnormal sleep behaviors.

What are the typical dosages for Trazodone and Ambien in treating sleep-related issues?

Typical Trazodone dosage ranges from 25 to 150 mg. Meanwhile, the dosage for Ambien usually ranges from 5 to 10 mg. The prescribed quantity also depends on the individual and formulation used.